We study the existence of long-lived meta-stable supersymmetry breaking vacua in gauge theories with massless quarks, upon the addition of extra massive flavors. A simple realization is provided by a modified version of SQCD with N_f,0 < N_c massless flavors, N_f,1 massive flavors and additional singlet chiral fields. This theory has local meta-stable minima separated from a runaway behavior at infinity by a potential barrier. We find further examples of such meta-stable minima in flavored

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... ons of quiver gauge theories on fractional branes at singularities with obstructed complex deformations, and study the case of the dP_1 theory in detail. Finally, we provide an explicit String Theory construction of such theories. The additional flavors arise from D7-branes on non-compact 4-cycles of the singularity, for which we find a new efficient description using dimer techniques.