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Mechanisms of Group I mGluR-Dependent Long-Term Depression of NMDA Receptor–Mediated Transmission at Schaffer Collateral–CA1 Synapses
Journal of Neurophysiology
Ireland DR, Abraham WC. Mechanisms of group I mGluR-dependent long-term depression of NMDA receptor-mediated transmission at Schaffer collateral-CA1 synapses. The mechanisms underlying group I metabotropic glutamate receptor (mGluR)-dependent long-term depression (LTD) of N-methyl-D-aspartate receptor (NMDAR)-mediated synaptic currents (EPSCs NMDAR ) are poorly understood. Here we investigated the effects of (R,S)-3,5-dihydroxyphenylglycine (DHPG), a selective agonist of group I mGluRs, on thedoi:10.1152/jn.90643.2008 pmid:19109458 fatcat:ppdo2cdhlnh4njrmraqwsferke