A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2018; you can also visit the original URL.
The file type is
Mitochondrial ATP-Sensitive Potassium Channel: A Novel Site for Neuroprotection
Investigative Ophthalmology and Visual Science
PURPOSE. It has been shown that bradykinin (BK) protects retinal neurons against glutamate excitotoxicity, but it was not clear how BK inhibits glutamate excitotoxicity. The purpose of this study was to investigate the effect of opening the mitochondrial adenosine triphosphate (ATP)-sensitive potassium (Mit K (ATP)) channel on glutamate excitotoxicity and the protective effect of BK using cultured retinal neurons. METHODS. Primary cultures were obtained from the retina of fetal rats (gestationdoi:10.1167/iovs.02-0815 pmid:12766083 fatcat:3vxno745xncw3ao3kqj4ujojhe