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Early detection of cancer saves lives, but an effective detection strategy in public health settings requires a delicate balance - periodic screening should neither miss rapidly progressing disease nor fail to detect rare tumors at unusual locations; on the other hand, even a modest false positive rate carries risks of over-diagnosis and over-treatment of relatively indolent non-malignant disease. Genomic profiling of cell-free DNA from liquid biopsy using massively parallel sequencing isdoi:10.3389/fgene.2021.759832 pmid:34721546 pmcid:PMC8551553 fatcat:xrxm6pni5vfztbh4plgvdk75fi