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Intrinsic Disorder in the Human Spliceosomal Proteome
2012
PLoS Computational Biology
The spliceosome is a molecular machine that performs the excision of introns from eukaryotic pre-mRNAs. This macromolecular complex comprises in human cells five RNAs and over one hundred proteins. In recent years, many spliceosomal proteins have been found to exhibit intrinsic disorder, that is to lack stable native three-dimensional structure in solution. Building on the previous body of proteomic, structural and functional data, we have carried out a systematic bioinformatics analysis of
doi:10.1371/journal.pcbi.1002641
pmid:22912569
pmcid:PMC3415423
fatcat:6cnd5mpd7ffd5lyzqfyfk2xgym