MiR-382 functions as tumor suppressor and chemosensitizer in colorectal cancer

Hui Yao, Dong Xia, Zong-lin Li, Lei Ren, Ming-ming Wang, Wang-sheng Chen, Zheng-chuan Hu, Guo-ping Yi, Liang Xu
2018 Bioscience Reports  
Increasing evidence suggests that microRNAs (miRNAs) play a critical role in tumorigenesis. Decreased expression of miR-382 has been observed in various types of cancers. However, the biological function of miR-382 in colorectal cancer (CRC) is still largely unknown. Here, we found that miR-382 was down-regulated in human colorectal cancer tissues and cell lines associated with it. MiR-382 inhibited colorectal cancer cell proliferation, migration, invasion, and enhance chemosensitivity.
more » ... ore, we identified Krüppel-like factor 12 (KLF12) and homeodomain-interacting protein kinase 3 (HIPK3) as the target of miR-382, and miR-382 rescued the promotion effect of KFL12 on migration and enhanced chemosensitivity in colorectal cancer cell lines. Collectively, these findings revealed that miR-382 inhibits migration and enhances chemosensitivity by targeting KLF12 and HIPK3 in colorectal cancer. These findings might serve as a tumor suppressor in CRC.
doi:10.1042/bsr20180441 pmid:29700213 pmcid:PMC6689104 fatcat:5egyfzkbuvcozg4kmh44mvmucu