Chronic obstructive pulmonary disease is a public health problem cause mortality. Palliative intervention is supportive in managing, and helping clients living with chronic obstructive pulmonary disease. Aim: This study aims to evaluate the effect of palliative care intervention for mitigating fatigue and sleep inefficiency among chronic obstructive pulmonary disease clients. Design: A quasi-experimental design was used. Setting: The study was conducted in Chest Outpatient Clinic, Ain Shams

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... ersity Hospitals. Sample: A purposive sample comprised of 70 clients. Tools: A structured interview questionnaire was used to collect the data and included three parts: Part I. Client's demographic characteristics. Part II. The Pittsburgh Sleep Quality Index. Part III. Fatigue Severity Scale. Results: The sleep quality index was improved from 7.1% of clients had good sleep quality pre intervention to 85.7% post intervention and also fatigue severity was improved from 90% of them had high fatigue pre intervention to 4.3% post intervention with highly statistically significant positive correlation between total fatigue and sleep quality index among chronic obstructive pulmonary disease clients (p= <0.001). Conclusion: The palliative care intervention had a positive effect on chronic obstructive pulmonary disease clients and helped them to mitigate sleep inefficiency, which led to reduce fatigue. Recommendations: An illustrated booklet containing information about benefits of gradual relaxation exercises should be available in all chest outpatient clinics. Training of the nurses on how to apply the palliative care intervention to chronic obstructive pulmonary disease clients.