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FemaleAedes aegyptimosquitoes bite humans to obtain a blood-meal to develop their eggs. Remarkably, strong attraction to humans is suppressed for several days after the blood-meal by an unknown mechanism. We investigated a role for neuropeptide Y (NPY)-related signaling in this long-term behavioral suppression, and discovered that drugs targeting human NPY receptors modulate mosquito host-seeking behavior. In a screen of all 49 predictedAe. aegyptipeptide receptors, we identified NPY-likedoi:10.1101/393793 fatcat:clgj4c6birai5di7vsdsphqdpa