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Ghrelin Receptor Gene: Identification of Several Sequence Variants in Extremely Obese Children and Adolescents, Healthy Normal-Weight and Underweight Students, and Children with Short Normal Stature
2004
Journal of Clinical Endocrinology and Metabolism
GH secretagogue receptor (GHSR, ghrelin receptor) is involved in regulation of body weight and GH secretion. We initially analyzed two single-nucleotide polymorphisms of the GHSR in up to 184 extremely obese children and adolescents and up to 184 healthy underweight students. The frequency of the 171T allele of rs495225 was higher in our obese samples (75.0%) than in the underweight individuals (70.2%; nominal P ؍ 0.14). This trend could not be substantiated in an additional association study
doi:10.1210/jc.2003-031395
pmid:14715843
fatcat:oewex75wvrh3dlewtmlajxv7de