Stability of Gabexate Mesilate

DENJI SHINKUMA, TSUNEO HAMAGUCHI, CHIKAAKI MURO, YOU YAMANAKA, NOBUYASU MIZUNO
1979 Japanese Journal of Hospital Pharmacy  
Stability of gabexate mesilate (GM) in aqueous solution was studied. In buffer solutions at a constant pH between 1 and 7, hydrolysis of GM occurred in accordance with pseudo first-order kinetics. The stability of GM reached maximum at pH 3 and decreased with an increasing pH of buffer solution. Ionic strength did not influence the hydrolysis rate but concentration of buffer solution affected hydrolysis.
doi:10.5649/jjphcs1975.5.186 fatcat:reyrs55s7bgoxjbitolzi5sjgm