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Biosynthesis of Prion Protein Nucleocytoplasmic Isoforms by Alternative Initiation of Translation
2008
Journal of Biological Chemistry
The cellular prion protein PrP C is synthesized as a family of four distinct forms. Of these, Cyt PrP is a minor member that segregates outside of the secretory route and can generate cytotoxic forms. Using signal sequence mutants, we found that Cyt PrP is translated from a downstream AUG (coding for Met-8 in human PrP or Met-15 in Syrian hamster PrP). Shortening of the signal sequence dictated the spillage of this isoform into the cytosol, from where it accessed the nucleus or formed insoluble
doi:10.1074/jbc.m804051200
pmid:19059915
fatcat:ag4eg6aqmrehbbuohntemomvq4