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3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Inhibitors Attenuate -Amyloid-Induced Microglial Inflammatory Responses
Journal of Neuroscience
Alzheimer's disease (AD) is characterized by extracellular deposits of fibrillar ␤-amyloid (A␤) in the brain, a fulminant microglialmediated inflammatory reaction, and neuronal death. The use of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) is associated with a reduced risk of AD, which has been attributed to the cholesterol-lowering actions of these drugs. Statins have been reported recently to have anti-inflammatory actions in addition to their classic lipid-loweringdoi:10.1523/jneurosci.2544-04.2005 pmid:15647473 fatcat:dw6dbjzgmjfkrb6p5nm373ugki