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Expression of Fas mRNA by liver MNC, consisting of extrathymic T cells, in mice
1994
Biomedical research
Fas antigen is known to be intimately associated with intrathymic T-cell differentiation through its apoptotic function, especially the elimination of self-reactive forbidden clones in a negative selection process. In addition to the intrathymic pathway of T-cell differentiation, an extrathymic pathway of T-cell differentiation was recently demonstrated to occur in the liver. To determine whether the Fas antigen is responsible for extrathymic differentiation, we examined herein the expression
doi:10.2220/biomedres.15.281
fatcat:p6c7xqdfmjhhbaypmpd6r4vgte