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Differential Regulation of Lympho-Myelopoiesis by Stromal Cells in the Early and Late Phases in BALB/c Mice Repeatedly Exposed to Lipopolysaccharide
Biological and Pharmaceutical Bulletin
Chronic lipopolysaccharide (LPS) exposure to mice reduces the lymphoid compartment and skews the hematopoietic cell compartment toward myeloid-cells, which is considered to be a direct effect of LPS on hematopoietic stem cells. However, the effect of chronic LPS exposure on stromal-cells, which compose the hematopoietic microenvironment, has not been elucidated. Here, we investigated early-and late-phase effects of repeated LPS exposure on stromal-cells. During the early phase, when mice weredoi:10.1248/bpb.b16-00375 pmid:27904036 fatcat:vujcqvxv6zeodetooso4uzqlqq