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Proceedings of the 3rd International Conference on Computation for Science and Technology
Polyphenols are widely presented in plants and dietary supplements. The beneficial effects of these compounds have been demonstrated, including the prevention of cardiovascular diseases, osteoporosis, neurogenerative diseases and diabetes. From previous studies, polyphenols showed the inhibitory effect on cytochrome P450 2C9 (CYP2C9) resulting in clinically significant of herb-drug interactions. CYP2C9 is involved in the biotransformation of various therapeutic drugs, including tolbutamide,doi:10.2991/iccst-15.2015.20 fatcat:oktdu2uw2baazpb4d6ww6cdd4y