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The structures of membrane transporters are still mostly unsolved. Only recently, the first two highresolution structures of transporters of the major facilitator superfamily (MFS) were published. Despite the low sequence similarity of the two proteins involved, lactose permease and glycerol-3-phosphate transporter, the reported structures are highly similar. This leads to the hypothesis that all members of the MFS share a similar structure, regardless of their low sequence identity. To testdoi:10.1110/ps.04657704 pmid:15215526 pmcid:PMC2279927 fatcat:icqjz3ncvngmzdshyy3xbd5pwq