Harnessing cloud computing with Galaxy Cloud

Enis Afgan, Dannon Baker, Nate Coraor, Hiroki Goto, Ian M Paul, Kateryna D Makova, Anton Nekrutenko, James Taylor
2011 Nature Biotechnology  
Continuing evolution of DNA sequencing has transformed modern biology. Reduced sequencing costs coupled with novel sequencing based assays has led to rapid adoption of next generation sequencing (NGS) across diverse areas of life science research [1] [2] [3] [4] . Sequencing has moved out of the genome centers into core facilities and individual labs where any investigator can access them for modest and progressively declining cost. While easy to generate in tremendous quantities, sequence data
more » ... is still difficult to manage and analyze. Sophisticated informatics techniques and supporting infrastructure are needed to make sense of even conceptually simple sequencing experiments -let alone the more complex analysis techniques being developed. The most pressing challenge facing the sequencing community today is providing the informatics infrastructure and accessible analysis methods needed to make it possible for all investigators to realize the power of high-throughput sequencing to advance their research. A possible solution to this infrastructure challenge comes in the form of "cloud computing", a model where computation and storage exist as virtual resources, accessed via the Internet, which can be dynamically allocated and released as needed 5 . Where previously acquisition of large amounts of computing power required significant initial and ongoing costs, the cloud model radically alters this by allowing computing resources and services to be acquired and paid for on demand. Importantly, cloud resources can provide storage and computation at far less cost than dedicated resources for certain use cases. For several specific applications, effective use of cloud resources has already been demonstrated [6] [7] [8] . In general however, cloud resources are not provided in a form that can be immediately used by a researcher without informatics expertise. Several commercial vendors provide cloudbased sequence analysis services through the web that hide all complexity of the underlying Users may view, print, copy, download and text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
doi:10.1038/nbt.2028 pmid:22068528 pmcid:PMC3868438 fatcat:bi254ehyubhzxgdat6sbuztt2e