303: Role of Extensive Splenomegaly in Patients with Myelofibrosis undergoing a Reduced Intensity Allogeneic Stem Cell Transplant

S.O. Ciurea, B. Sadegi, A. Wilbur, V. Alagiozian-Angelova, S. Gaitonde, L. Dobogai, L.P. Akard, R. Hoffman, D. Rondelli
2008 Biology of Blood and Marrow Transplantation  
D5S818) (ABI Prism 3130). The loci examined were classified as complete matched (CM), partially matched (PM), and fully mismatched (FMM) between donors and recipients. Results: The loci of D13S317, D18S51 and D2S1338 were the most informative, while the loci of TPOX and CSF1PO were the least. The incidence of acute GvHD was 46.7% (n 5 69), which acute severe GvHD (grII-IV) was observed in only 31 patients. Chronic GvHD was developed in 63.4% patients. The incidence of grII-IV GvHD was higher in
more » ... patient with CM in TPOX loci (p 5 0.02). Chronic GvHD was more frequent in the patients with PM in D5S818 loci than those with CM or MM (p 5 0.016). While PM D21S11 increased TRM, MM or PM in D5S818 loci decreased the TRM. In our cohort analysis, 2-year probability of disease-free survival(DFS) and overall survival(OS) were 58.1 6 5.5% and 67.5 6 4.4%, respectively. The CM in D21D11 locus (p 5 0.07) and PM in D5S818 locus (p 5 0.009) prolonged the probability of DFS. In multivariate analysis, these loci had an impact on DFS (p 5 0.055 ve p 5 0.005). D19S433 and D5S818 loci had an effect on the OS. We repeated similar analyses into two groups, mismatched (MM) group, which FMM and PM was accepted as a whole group or CM group, while the incidence of grII-IV GvHD was higher in patients with CM of D18S51 and TPOX loci, the chronic GvHD was more frequent in those with CM D5S820 loci. Similar as the first analyses MM in D21S11 and CM in D5S818 affected both TRM and DFS. Besides, MM in FGA locus decreased TRM and prolonged DFS. The impact of D5S818 on the OS also continued, additionally D19S433 had minimal effect on the OS. In conclusion, some disparities of STR loci might affect the transplantation outcome; however, these results should be analyzed together with other co-variates and on multicenter basis.
doi:10.1016/j.bbmt.2007.12.313 fatcat:le5ylclz5besjptzx2hbyx4cfu