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The purpose of this paper is to offer a comparative study on the fractal dimension (D) used to differentiate edges in brain images processed using first-order derivative filters (Prewitt, Roberts) and second-order derivative filters (Laplacian and Laplacian of Gaussian). PDw (proton density) and T2w (T2-weighted type) brain images of healthy patients and patients diagnosed with metastatic bronchogenic carcinoma (MBC) are used. Experimental results showed that secondorder derivative filtersdoi:10.35219/ann-ugal-math-phys-mec.2019.1.05 fatcat:zyu2d6c5tbhadjk6qdvpsvdx2e