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The effect of ISP-I/myriocin on adenosine 3′monophosphate (3′-AMP) forming enzyme activity in carbon tetrachloride (CCl 4 )-induced hepatitis was examined. The 3′-AMP forming enzyme activity in mouse liver was enhanced by the treatment of CCl 4 . The increase in the activity in cytosol may result from the leakage of the enzyme from mitochondria via the damage of mitochondrial membrane induced by CCl 4 . Pretreatment of mice with ISP-I/myriocin for 24 hr, significantly inhibited both the CCl 4doi:10.1248/jhs.47.314 fatcat:npuv6tnmxffstcn5qsbtuwk6ki