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Heparin protects Opa+ Neisseria gonorrhoeae from the bactericidal action of normal human serum
1995
Infection and Immunity
The pathobiological significance of lipooligosaccharide (LOS) and outer membrane opacity protein (Opa) changes in gonorrheal disease are poorly understood. We assessed variants of strain MS11mk with different LOS and Opa phenotypes for their liability to killing by normal human sera. LOS differences correlated with strikingly disparate susceptibilities to serum killing; LOSa variants were serum resistant, LOSb variants were serum sensitive, and sialylation of LOSb variants enhanced their
doi:10.1128/iai.63.5.1790-1795.1995
fatcat:q6i6u2fj4vhsngi2ligpjic4tu