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CEACAMs are cell surface proteins with immunoglobulin (Ig) folds that regulate cell communication, cell signalling and immunity. Several human bacterial pathogens express adhesins that bind CEACAMs for enhanced adhesion to epithelial surfaces. Here, we report an adhesin-CEACAM interaction with unique properties. We found β protein from the human neonatal Gram-positive bacterial pathogen Streptococcus agalactiae contains a domain with Ig superfamily (IgSF) fold that promotes binding to thedoi:10.1101/2020.06.09.141622 fatcat:ejh6uc7zlvcavfj6d2pojugpga