A Case of Colchicine-Induced Neutropenia in Liver Cirrhosis Patient

Ho Chan Lee, Heon Ju Lee, Yong Gil Kim, Jae Hyun Park, Sung Joon Kim, Jun Seok Park
2009 Yeungnam University Journal of Medicine  
Colchicine is an alkaloid that has been used for treating acute gouty arthritis, psoriasis, scleroderma and Behcet's syndrome. Colchicine decreased liver fibrosis in rats with carbon tetrachloride induced cirrhosis and in patients with many liver diseases. Therapeutic oral doses of colchicine may cause nausea, vomiting, abdominal pain and diarrhea. The adverse effect of colchicine associated with the dose is bone marrow suppression, and especially neutopenia. Neutropenia has often been reported
more » ... in patients have taken an overdose of colchicine. We describe a 64-year-old female liver cirrhosis patient with neutropenia that was induced by a therapeutic dose of colchicine. 서 론 콜히친은 급성 통풍이나 건선, 피부경화증, 베 체트병 등에 전 세계적으로 널리 쓰이는 알칼로 이드계 약물이다. 1) 콜히친이 Carbon tetrachloride 에 의해 손상된 쥐의 간을 회복시키고, 2) 인간 의 다양한 간질환에 대해서도 섬유화를 감소시 키며, 생존률에 대한 굉장한 호전이 보고된 바 책임저자:이헌주, 대구광역시 남구 대명5동 317-1, 영남대학교 의과대학 내과학교실
doi:10.12701/yujm.2009.26.2.125 fatcat:zczjsvxdhfhgjohypiz2ku6xr4