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Low- and Standard-Dose Corticotropin and Insulin Hypoglycemia Testing in the Assessment of Hypothalamic-Pituitary-Adrenal Function after Pituitary Surgery
Journal of Clinical Endocrinology and Metabolism
The optimal means of assessing the integrity of the hypothalamic-pituitary-adrenal (HPA) axis after pituitary surgery remains controversial. We compared low-dose (1 g iv) and standard-dose (250 g im) corticotropin tests performed 1 and 4 -6 wk after pituitary surgery with an insulin hypoglycemia test performed at 4 -6 wk. Forty-one patients (21 male and 20 female; median age, 52 yr; range, 23-73 yr) who had undergone pituitary surgery were studied (Cushing's disease excluded). Twenty-two of thedoi:10.1210/jc.2003-031577 pmid:15070935 fatcat:ozmnwuzzsze2lc7si6shxuv66q