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In this paper, a multiplexer has been designed and layout simulated using 90nm in Auto generated and semicustom design mode. The schematic of 4:1 multiplexer has been designed using and its equivalent layout is created using micro wind tools. The Performance has been analyzed and compared in terms of area and power. It can be observed from simulated results in semicustom that 75% reduction in area and 6.6% reduction in powerfatcat:ysnk2ir6izgupik5iuzb3i34cy