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Biological Studies on Kanamycin-Di-N- and Tetra-N-Methanesulfonates and Fradiomycin (Neomycin)-N-Methanesulfonate
1959
As reported by T J\KEUCHI, et al.' ', kanamycin was adsorbed by phosphoprotein fraction of egg yolk or a similar fraction of ground brain and eluted by acid aqueous methanol or acid water. This modus of adsorption and elution suggests that the mechanism of this adsorption on high molecular acid substances in the tissue such as phosphoproteins is similar to that on cation exchange resin. Kanamycin which has basic groups 2 l can be adsorbed on high molecular acid substances in the brain by ion
doi:10.11554/antibioticsa.12.4_117
fatcat:fuxd7zql65fblmlrkzf2y4bglu