A pericentric inv(11) (pl5q23) detectable by G-, Q-, and R-banding and occurring in 1 member ofeach of 3 generations of a family is described. In another family studied by several banding methods in search of chromosomal markers, a pericentric inv(l 1) (p1 1 q1 1) was found. It was detectable only by C-banding, the darkly staining band being located on the short-arm side of the centromere. The reasons for defining this aberration as an inversion rather than a location variant are outlined. This

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... inversion occurred in 9 members of 3 generations of a large family. There was no clear-cut evidence of any clinical consequences of these inversions either in heterozygotes or their offspring.