Cytokine and Leukocyte Profiling Reveal Pro-Inflammatory and Autoimmune Features in Frontotemporal Dementia Patients [article]

Philipp A. Jaeger, Trisha M. Stan, Eva Czirr, Markus Britschgi, Daniela Berdnik, Ruo-Pan Huang, Bradley F. Boeve, Adam L. Boxer, NiCole Finch, Gabriela K. Fragiadakis, Neill R. Graff-Radford, Ruochun Huang (+12 others)
2016 bioRxiv   pre-print
The growing link between systemic environment and brain function opens the possibility that cellular communication and composition in blood are correlated with brain health. We tested this concept in frontotemporal dementia with novel, unbiased tools that measure hundreds of soluble signaling proteins or characterize the vast immune cell repertoire in blood. With these tools we discovered complementary abnormalities indicative of abnormal T cell populations and autoimmunity in frontotemporal dementia.
doi:10.1101/049791 fatcat:f6u4ak3gnzeivlhfmqkra2eqsi