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Effects of icariin and quercetin on high glucose-induced neuronal cell apoptosis
2020
Tropical Journal of Pharmaceutical Research
Purpose: To study the effects of icariin and quercetin on cell apoptotic changes in neurons induced by elevated glucose condition, and the mechanism involved. Methods: Neonatal male Sprague Dawley rats (n = 48) weighing 5 – 7 g were used. Neuronal cells were isolated from rat hippocampus and cultured after purification. The cells were randomly assigned to six groups: control, high glucose, icariin, quercetin, serine/threonine-specific protein kinase (Akt) inhibitor, and Akt agonist groups. The
doi:10.4314/tjpr.v19i6.10
fatcat:4ewrmswydjdx7aj342mty5gnhu