Original Article Correlation of HLA-DQB1 gene polymorphism of Xinjiang Uygur with outcome of HBV infection

Yongping Zhang, Fengcong Zhao, Liu Lan, Zhao Qin, Jun Liang
2015 Int J Clin Exp Med   unpublished
The aim of this study was to explore the correlation of gene polymorphisms of human leuko-cyte antigen-DQB1 (HLA-DQB1) with the infection outcome and replication status of hepatitis B virus (HBV) positive patients in the Xinjiang Uygur population in China. Methods: 110 cases of chronic hepatitis B (CHB) of Xinjiang Uygur were examined clinically, which were named as the CHB group; 100 cases carrying chronic HBV (ASC) served as ASC group; 80 cases of self-limited HBV infection (RHBS) were
more » ... (RHBS) were recorded as RHBS group. Genotypes of HLA-DQB1 were detected by sequence specific primer-polymerase chain reaction (PCR-SSP) method, and the differences of gene frequency among groups were also compared. The distribution frequencies of the HLA-DQB1 gene under different replication states of HBV were compared. Results: The distribution frequency of DQB1*0201 in the RHBS group was higher than that of the ASC group (18.75%, 10.50%, χ 2 = 5.959, P < 0.05, OR = 2.257). The distribution frequency of DQB1*0201 in the CHB group was higher than that of the ASC group (17.73%, 10.50%, χ 2 = 5.363, P < 0.05, OR = 2.066). The distribution frequency of DQB1*0301 in the CHB group was higher than that of the ASC group (26.82%, 16.50%, χ 2 = 9.062, P < 0.05, OR = 2.349). The distribution frequency of DQB1*0303 in the CHB group was lower than that of the ASC group (19.55%, 31.00%, χ 2 = 10.996, P < 0.05, OR = 0.393). There was no statistically significant difference in the allele frequencies among all other groups. The distribution frequency of DQB1*0201 in the low replication group was higher than that of the high replication group (17.08%, 10.56%, χ 2 = 4.295, P < 0.05, OR = 1.939). Conclusion: HLA-DQB1*0201 is a HBV resistance gene in Xinjiang Uygur. DQB1*0301 is correlated with continuous infection of HBV. DQB1*0303 is a susceptibility gene of ASC.
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