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Radioadaptation/I-SceI digestion/DSB repair/TK6 cells. In this review, we would like to introduce a unique approach for the estimation of radioadaptation. Recently, we proposed a new methodology for evaluating the repair efficiency of DNA double-strand breaks (DSB) using a model system. The model system can trace the fate of a single DSB, which is introduced within intron 4 of the TK gene on chromosome 17 in human lymphoblastoid TK6 cells by the expression of restriction enzyme I-SceI. Thisdoi:10.1269/jrr.09050 pmid:19680010 fatcat:ozbi7jlpzbc7nhuhjdu6iszp44