The Nature and Determinants of Neuropsychological Functioning in Late-LifeDepression

Meryl A. Butters, Ellen M. Whyte, Robert D. Nebes, Amy E. Begley, Mary Amanda Dew, Benoit H. Mulsant, Michelle D. Zmuda, Rishi Bhalla, Carolyn Cidis Meltzer, Bruce G. Pollock, Charles F. Reynolds, James T. Becker
2004 Archives of General Psychiatry  
Context: Cognitive impairment in late-life depression (LLD) is highly prevalent, disabling, poorly understood, and likely related to long-term outcome. Objectives: To determine the characteristics and determinants of neuropsychological functioning LLD. Design: Cross-sectional study of groups of LLD patients and control subjects. Setting: Outpatient, university-based depression research clinic. Participants: One hundred patients without dementia 60 years and older who met DSM-IV criteria for
more » ... ent episode of unipolar major depression (nonpsychotic) and 40 nondepressed, age-and education-equated control subjects. Main Outcome Measures: A comprehensive neuropsychological battery. Results: Relative to control subjects, LLD patients performed poorer in all cognitive domains. More than half exhibited significant impairment (performance below the ORIGINAL ARTICLE
doi:10.1001/archpsyc.61.6.587 pmid:15184238 fatcat:c2bdhw64cvfc3neioevyay4qtq