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HuR Suppresses Fas Expression and Correlates with Patient Outcome in Liver Cancer
Molecular Cancer Research
Hepatocellular carcinomas (HCC) show resistance to chemotherapy and have blunt response to apoptotic stimuli. HCC cell lines express low levels of the Fas death receptor and are resistant to FasL stimulation, whereas immortalized hepatocytes are sensitive. The variable Fas transcript levels and consistently low Fas protein in HCC cells suggest posttranscriptional regulation of Fas expression. The 3 0 -untranslated region (UTR) of Fas mRNA was found to interact with the ribonucleoprotein Humandoi:10.1158/1541-7786.mcr-14-0241 pmid:25678597 fatcat:qlabk7pmjfcobfwk4kzo6q64qe