Application of Various Equations for Estimating GFR in Patients with Type 1 Diabetes

M. V. Kaplanian, A. B. Hodzhayan, M. G. Gevandova, K. S. Elbekyan, E. V. Kaplanova, K. R. Amlaev
2020 American Journal of Internal Medicine  
To compare different methods of estimating glomerular filtration rate (GFR) calculated by creatinine and cystatin C in patients with type 1 diabetes with normal and moderately decreased renal filtration function. The study involved 57 patients with type 1 diabetes, 37 men and 20 women, aged from 21 to 57 years (median 30 years), with disease duration after diagnosis from 33 to 2 years (median 8 years). The control group comprised 15 non-diabetic people aged 19 to 42 years (median -28 years),
more » ... dian -28 years), with normal levels of albuminuria and blood creatinine. The majority of patients with type 1 diabetes were found to have decompensated diabetes mellitus. The mean value of glycated hemoglobin in patients was 8%. The renal glomerular function was estimated by level of GFR and triple testing of urine albumin excretion. Renal tubular function in type 1 diabetes was tested by examining serum cystatin C. GFR estimating equations, which did not include serum of cystatin C produced higher GFR. As a result, the majority of patients had normal or elevated GFR showing hyperfiltration. Using cystatin-C-based equations resulted in a several-fold reduction in the number of patients with hyperfiltration and increased number of cases with GFR below 90 ml/min/m 2 . The assessment of the relationship between SDMA and GFR showed negative correlation with both cystatin-C-based and creatinine-based equations. These findings revealed that GFR estimating equations based on both creatinine and cystatin C produce more accurate results compared with the reference estimating equations.
doi:10.11648/j.ajim.20200802.15 fatcat:xsn5sglkabholkevu5nndtcami