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Japanese Journal of Medicine
Familial primary pulmonary hypertension was found in two siblings (sister and brother). The woman noted exertional dyspnea at the age of 28 yr. The younger brother noticed exertional dyspnea, cough with bloody sputum and pretibial edema at the age of 38 yr. Wediagnosed them as primary pulmonary hypertension as based on hemodynamicand histopathological findings. Regardless of the treatment, both patients died of right-sided heart failure with a short time course. Weexamined their family members,doi:10.2169/internalmedicine1962.30.273 fatcat:y6la2qu3xrelrhuyhb5ufnsjze