Tamoxifen inhibits mitochondrial membrane damage caused by disulfiram

Natalia Pavón, Mabel Buelna-Chontal, Francisco Correa, Belem Yoval-Sánchez, Javier Belmont, Luz Hernández-Esquivel, José S. Rodríguez-Zavala, Edmundo Chávez
2017 Biochemistry and Cell Biology  
In this work, we studied the protective effect of tamoxifen on disulfiraminduced mitochondrial membrane insult. The results indicate that tamoxifen circumvents inner membrane leakiness manifested by Ca 2+ release, mitochondrial swelling, and collapse of the transmembrane electric gradient. Furthermore, it was found that tamoxifen prevents the inactivation of the mitochondrial enzyme aconitase and detachment of cytochrome c from the inner membrane. Interestingly, tamoxifen also inhibited
more » ... o inhibited disulfiram-promoted generation of hydrogen peroxide. Given that tamoxifen is an antioxidant molecule, it is plausible that its protection may be due to the inhibition of disulfiram-induced oxidative stress.
doi:10.1139/bcb-2017-0027 pmid:28595020 fatcat:y4vegvmycbdwppbbezqtzzzehu