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Computational Study on the Different Ligands Induced Conformation Change of β2 Adrenergic Receptor-Gs Protein Complex
2013
PLoS ONE
b 2 adrenergic receptor (b 2 AR) regulated many key physiological processes by activation of a heterotrimeric GTP binding protein (Gs protein). This process could be modulated by different types of ligands. But the details about this modulation process were still not depicted. Here, we performed molecular dynamics (MD) simulations on the structures of b 2 AR-Gs protein in complex with different types of ligands. The simulation results demonstrated that the agonist BI-167107 could form hydrogen
doi:10.1371/journal.pone.0068138
pmid:23922653
pmcid:PMC3726664
fatcat:5lyookbjmnc2dexbdh6h7kgnuq