Response to Comment on "SUMO deconjugation is required for arsenic-triggered ubiquitylation of PML"

Domenico Fasci, Veronica Anania, Jennie Lill, Guy Salvesen
2016 Science Signaling  
Arsenic trioxide chemotherapy cures acute promyelocytic leukemia by inducing the ubiquitylation of an oncogenic fusion protein containing promyelocytic leukemia protein (PML) subsequent to modification of PML by SUMO1 and SUMO2. We proposed that the SUMO switch at Lys 65 of PML enhanced subsequent SUMO2 conjugation to Lys 160 and consequent RNF4-dependent ubiquitylation of PML. Ferhi et al. note differences between their experimental system and ours regarding the outcome and mechanisms of
more » ... ependent PML signaling. When confronted by apparently contradictory data, it is appropriate to drill down to where the differences could lie.
doi:10.1126/scisignal.aad9777 pmid:27507652 fatcat:6y3secucp5ecrlh35oqt4jwhsy