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Synthesis and Antiproliferative Activity of New Aminoisoquinolinylurea Derivatives against Melanoma Cell Line
2012
Bulletin of the Korean Chemical Society (Print)
Preserved Fulltext
A series of new diarylureas possessing aminoisoquinoline scaffold was synthesized, and their in vitro antiproliferative activity against A375P human melanoma cell line was tested. Compounds 1d, 1l, 1n, 1p, 1q, and 1t showed superior potency against A375P to Sorafenib. The highest potency was shown by compound 1p possessing 3,5-bis(trifluoromethyl)phenyl terminal ring with IC 50 value of 0.41 µM.
doi:10.5012/bkcs.2012.33.11.3635
fatcat:obbpijyfqvfazlx3wsavhbv3ti