Medication related osteonecrosis of the jaw (MRONJ) represents a potential adverse effect related to the treatment with antiresorptive (Bisphosphonates, Denosumab) and antiangiogenic (Tyrosine kinase inhibitors, Vascular endothelial growth factor inhibitors) drugs. This condition could occur in patients that take these agents for the treatment of skeletal and oncological diseases but have no history of radiation therapy to the jaws. MRONJ is characterized by exposed bone or bone that can be

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... ed through an intraoral or extraoral fistula in maxillofacial region that has persisted for longer than 8 weeks [1] . The risk to develop osteonecrosis increases with local factors, especially dental infection and dentoalveolar surgery such as tooth extraction. Case presentation: This report describes a case of bisphosphonate related to osteonecrosis of the jaw associated with tooth infection and subsequent involvement of the nearby implant. Conclusion: The aim of this case is to describe the decision-making and clinical management of MRONJ carried out in ambulatory way and underline the importance of anamnesis and early diagnosis. Qeios, CC-BY 4.0 · Article,