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QT Assessment in Early Drug Development: The Long and the Short of It
2019
International Journal of Molecular Sciences
The QT interval occupies a pivotal role in drug development as a surface biomarker of ventricular repolarization. The electrophysiologic substrate for QT prolongation coupled with reports of non-cardiac drugs producing lethal arrhythmias captured worldwide attention from government regulators eventuating in a series of guidance documents that require virtually all new chemical compounds to undergo rigorous preclinical and clinical testing to profile their QT liability. While prolongation or
doi:10.3390/ijms20061324
fatcat:252k22yvsrbajahkws7yzxguh4