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GATA2-IGF2 Mediates Chemotherapy Resistance in Lethal Prostate Cancer
2015
Cancer Discovery
Preserved Fulltext
Major finding: IFNα/β enhances the cytotoxicity of MEK inhibition in melanoma cells with low basal STAT1 activity. Approach: A biclustering algorithm identified context-specific MAPK target genes that contribute to resistance. Impact : System-wide computational analyses of perturbations can predict drug response in patients. Vidal SJ, Rodriguez-Bravo V, Quinn SA, Rodriguez-Barrueco R, Lujambio A, Williams E, et al. A targetable GATA2-IGF2 axis confers aggressiveness in lethal prostate cancer.
doi:10.1158/2159-8290.cd-rw2015-033
fatcat:3gh5ewtgojglzot4j6vm4ubfei