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Expression of the K-Cl co-transporter KCC2 in cerebral cortex and thalamus during murine postnatal development
In the adult central nervous system GABA mediates fast inhibitory transmission, whereas during development it is an excitatory transmitter and a trophic factor involved in controlling morphogenesis (Ben-Ari, 2002). This funcional shift occurs as a result of a progressively increasing expression of the KCC2 cotransporter, the major chloride extruder in mature neurons. In several pathological conditions associated with hyperexcitability, such as epilepsy, suppression of KCC2 may contribute todoi:10.13128/ijae-13910 fatcat:utqwi4agcvghvpnxcrrwxhmwwq