Place-cell capacity and volatility with grid-like inputs

Man Yi Yim, Lorenzo A Sadun, Ila R Fiete, Thibaud Taillefumier
2021 eLife  
What factors constrain the arrangement of the multiple fields of a place cell? By modeling place cells as perceptrons that act on multiscale periodic grid-cell inputs, we analytically enumerate a place cell's repertoire - how many field arrangements it can realize without external cues while its grid inputs are unique; and derive its capacity - the spatial range over which it can achieve any field arrangement. We show that the repertoire is very large and relatively noise-robust. However, the
more » ... pertoire is a vanishing fraction of all arrangements, while capacity scales only as the sum of the grid periods so field arrangements are constrained over larger distances. Thus, grid-driven place field arrangements define a large response scaffold that is strongly constrained by its structured inputs. Finally, we show that altering grid-place weights to generate an arbitrary new place field strongly affects existing arrangements, which could explain the volatility of the place code.
doi:10.7554/elife.62702 pmid:34028354 pmcid:PMC8294848 fatcat:fu7ajpzv4vfc7jwwejfoavepie