SAT0133 Predictors of pain and its change over time in fibromyalgia

PH Dessein, AE Stanwix, Z Moomal
2001 Speaker abstracts 2001   unpublished
Widespread pain is the central feature of fibromyalgia (FM). The role of physical as opposed to psychological mechanisms in FM pain remains a matter of controversy. Objectives In the present study, we evaluated the dependency of FM pain on other FM clinical features as assessed by the Fibromyalgia Impact Questionnaire (FIQ). Methods Forty two consecutive patients, who had been followed up for at least 2 months, were enrolled. Their mean (SD, range) age, disease duration and follow up duration
more » ... ollow up duration were 42 (12, 15-78), 8 (11, 0.3-45) and 2.9 (2.2, 0.28 -8.6) years, respectively. They completed FIQ scores as applied to their health status at enrolment in the clinic and at the time of the study. Statistical analyses were done by simple linear regression analyses and oneway analysis of variance. Results were expressed as mean (SD) and a p < 0.05 was considered significant. Results The pain visual analogue scale was 8.9 (1.3) at enrolment versus 2.4 (1.9) at the time of the study (p < 0.001). At enrolment, pain was predicted by morning tiredness (p < 0.001), FM symptom interference with work (p < 0.001) and stiffness (p = 0.001). At the time of the study, pain was predicted by tiredness (p < 0.001), morning tiredness (p < 0.001), FM symptom interference with work (p = 0.003) and stiffness (p = 0.03). Improvement in pain was predicted by pain at enrolment (p = 0.007) (and by no other baseline FIQ scores) and improvements in tiredness (p < 0.001), morning tiredness (p < 0.001), FM symptom interference with work (p < 0.001) and stiffness (p = 0.002). Conclusion Pain and fatigue were strongly interrelated in our FM patients. The physical symptoms fatigue, stiffness and FM symptom interference with work consistently predicted FM pain and its change over time. In contrast, the psychological variables anxiety and depression, as assessed by the FIQ, did not relate to FM pain. Background The efficacy of treatment programs in fibromyalgia (FM) as currently used in practice is unsatisfactory and more innovative and effective therapies need to be developed. Objectives The present study comprises part of an audit of a rheumatology clinic in which central sensitisation and neuroendocrine deficiencies were considered in the evaluation and management of FM. Methods Forty two consecutive female FM (22 primary; 20 sary) patients, who had been followed up for at least 2 months,
doi:10.1136/annrheumdis-2001.592 fatcat:wab2kxgbgvffnc64fpmn4q3it4