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L-arginine/nitric oxide amplifies the magnitude and duration of the luteinizing hormone surge induced by estrogen: involvement of neuropeptide Y

J J Bonavera, P S Kalra, S P Kalra
1996 Endocrinology  

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https://web.archive.org/web/20180729150407/https://watermark.silverchair.com/endo1956.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAawwggGoBgkqhkiG9w0BBwagggGZMIIBlQIBADCCAY4GCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMOaNtWnV9pcnceun3AgEQgIIBX1tWy3jCwofrHx0k-STi1WtYQRueQu371ejW428-0qYm7DB6nGV0buwKsrM4ObuWtyvHoZxPjoYaPEum_oP4yb6EzBg8bd7Dww4cErgTf-9-OkroQa2esCBWbBpR4PmMUEotjdWphn_306GBaofKwqyoBbsXRULNcA_OaNSXctgPAIxglVxCz79vzc8pzZiq0g-wh47nPYIvcllbPW2wDWz4_Qgs7PxHX80aZ_1GVllejEsek0J9zT4VRFshZxgR9j9ApXE2EQevkjrfWzOF0Z7sQ-mmpSbwJyHIym7zhykpqXvQFLyc4l1h71dyeSdxQxWvvi_FWGeHLPz41bVABgGANnZEik2r6YmrsBH1XO14S7tDR11Kbc-Tk5ZGk0l4yN-Cs6Sg0n455x68VyLW03dDyb6Ix89_KnLVPCBM5ZRuIpyg8G73Fdj7mklNuWTihZxSSvQFFACISl49l9I2tw

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Although estrogen can induce LH hypersecretion in ovariectomized (0~x1 rats, the magnitude and duration of the LH surge are invariably far less than those of the preovulatory LH surge in cycling rats. Recently, the crucial roles of hypothalamic nitric oxide (NO) and neuropeptide Y (NPY) in the induction of LHRH and the LH surge have been recognized.
doi:10.1210/endo.137.5.8612536 pmid:8612536 fatcat:b2efxk64pjenjenz77vdbwp7e4
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J J Bonavera, P S Kalra, S P Kalra. "L-arginine/nitric oxide amplifies the magnitude and duration of the luteinizing hormone surge induced by estrogen: involvement of neuropeptide Y." Endocrinology 137.5 (1996) 1956-1962