Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4,5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that coiled-coil domain-containing protein 132, encoded by CCDC132, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to

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... ry tumors of the breast. CCDC132 mRNA was present at decreased quantities in brain metastatic tissues as compared to primary tumors of the breast. Importantly, expression of CCDC132 in primary tumors was significantly correlated with patient recurrence-free survival. Modulation of CCDC132 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.