The p38 Pathway Regulates Oxidative Stress Tolerance by Phosphorylation of Mitochondrial Protein IscU

Lili Tian, Jianming Chen, Mingliang Chen, Chloe Gui, Chuan-qi Zhong, Lixin Hong, Changchuan Xie, Xiurong Wu, Lirong Yang, Vakil Ahmad, Jiahuai Han
2014 Journal of Biological Chemistry  
The p38 pathway is an evolutionarily conserved signaling pathway that responds to a variety of stresses. Results: dIscU can be phosphorylated by dMK2, thereby impacting mitochondrial respiratory complex I activity. Conclusion: Iron-sulfur cluster protein IscU phosphorylation by MK2 downstream of p38 signaling may regulate oxidative stress tolerance. Significance: IscU is a novel substrate of MK2, mechanistically connecting the p38 pathway and mitochondria iron-sulfur clusters for the first time.
doi:10.1074/jbc.m114.589093 pmid:25204651 pmcid:PMC4231663 fatcat:tzfyey5yuvfp3c7pom7sirctla