Inhibitory Effect of Penthorun chinense Extract on Allergic Responses in vitro and in vivo
낙지다리 식물 추출물의 알레르기 억제효과

So young Jo, Young Mi Kim
2015 Journal of Food Hygiene and Safety  
Allergic diseases have rapidly increased in recent years. Mast cells play a critical role in IgE-mediated allergy responses and, therefore, closely associated with rhinitis, asthma, and atopic dermatitis. We studied antiallergic effect of Penthorum chinense extract (PCE) in vitro and in vivo. PCE inhibited the degranulation of mast cells by antigen stimulation and its effect was dose-dependent and reversible in mast cells. PCE also suppressed the production of inflammatory cytokines such as
more » ... α and IL-4 by antigen in mast cells. Mechanistically, PCE inhibited the activation of Syk/LAT pathway which is a key signaling pathway for the activation of mast cells by antigen. Notably, PCE suppressed IgE-mediated allergic responses by antigen in mice. These results strongly suggest that PCE is a potential candidate for anti-allergic treatment.
doi:10.13103/jfhs.2015.30.4.376 fatcat:cddqkcd2xjbwxhu3gexoxp37uq