We develop a cyclical blockwise coordinate descent algorithm for the multi-task Lasso that efficiently solves problems with thousands of features and tasks. The main result shows that a closed-form Winsorization operator can be obtained for the sup-norm penalized least squares regression. This allows the algorithm to find solutions to very largescale problems far more efficiently than existing methods. This result complements the pioneering work of Friedman, et al. (2007) for the single-task

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... so. As a case study, we use the multi-task Lasso as a variable selector to discover a semantic basis for predicting human neural activation. The learned solution outperforms the standard basis for this task on the majority of test participants, while requiring far fewer assumptions about cognitive neuroscience. We demonstrate how this learned basis can yield insights into how the brain represents the meanings of words.